The Armenians of Kessab and the surrounding villages are the remainders of migrants who came from the region of Antioch. The migration of the Armenians to the region increased in the 14th and the 15th centuries, during the Memluk and the Ottoman periods, in an attempt to avoid persecution. In 1915, the genocide of the Armenians in Kessab region started from Karadouran. The Armenians were deported in two directions: one towards the desert of Deir ez-Zor and the other towards the south to the desert of Jordan. Almost five thousand Armenians were killed during this deportation process. Some died in Jeser Al Shoughour, some in Hama or Homs while others on the way to Damascus or Jordan. The majority of the refugees were killed in the desert of Der Zor. Far more casualties ocurred in the actual Armenian territory, at the hands of the Turks.
After the cease-fire, the Armenians who survived the genocide
returned to Kesab in a process that lasted till 1920.